High Risk Apml Treated Successfully with Four Cycles of ATO and ATRA Combination in Resource Constrained Settings

ATRA and ATO team up against NPM1.

In this issue of Blood, Martelli et al and El Hajj et al independently report that nucleophosmin-1 (NPM1)-mutant leukemia is particularly vulnerable to a novel strategy combining all-trans retinoic acid (ATRA) with arsenic trioxide (ATO). The era of targeted therapy has seen some of its greatest successes in the hematologic arena (eg, breakpoint cluster region [BCR]/Abelson [ABL] kinase inhibit...

the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region

چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...

The Continued Utility and Viability of Dakin’s Solution in Both High- and Low-resource Settings

Healthcare is expensive and often inaccessible to many. As a result, surgeons must consider simple, less expensiveinterventions when possible. For wound care, an older but quite effective cleaning agent is Dakin’s solution (0.5%sodium hypochlorite), an easily made mixture of 100 milliliters (ml) bleach with 8 teaspoons (tsp) baking soda into agallon of clean water or 25 ml ble...

treatment outcomes of adolescents with drug-resistant tuberculosis in resource-constrained settings

Querying Uncertain Data in Resource Constrained Settings

Querying Uncertain Data in Resource Constrained Settings